Figure 4
From: ST6Gal-I sialyltransferase confers cisplatin resistance in ovarian tumor cells
shRNA-mediated ST6Gal-I knockdown sensitizes Pa-1 cells to cisplatin-induced cell death. (A) Pa-1 cells with stable ST6Gal-I knockdown (sh.ST6) are sensitized to cisplatin-induced cell death, as measured by ATP content. Means and S.E.M.s are shown for a representative experiment, with three independent experiments performed, and each experiment performed in triplicate. (B) sh.ST6 cells have increased levels of cleaved caspase-3 following cisplatin treatment as compared with Par cells.