Figure 5
From: ST6Gal-I sialyltransferase confers cisplatin resistance in ovarian tumor cells
Cells that are resistant to cisplatin have upregulated endogenous ST6Gal-I. (A) Pa-1 cells with ST6Gal-I knockdown (sh.ST6) were exposed to cisplatin for 3 weeks, and the remaining viable population (sh.ST6 cis-res) was expanded and immunoblotted for ST6Gal-I. (B) Pa-1 cells with ST6Gal-I knockdown do not upregulate ST6Gal-I expression following a 24-hr treatment with cisplatin (sh.ST6 + cis). (C) Parental A2780 ovarian cancer cells (Par) and a cisplatin-resistant derivative population (Cis-res) were immunoblotted for endogenous ST6Gal-I.