Figure 1
From: Safe and targeted anticancer therapy for ovarian cancer using a novel class of curcumin analogs
Structures of curcumin, EF24 (3,5-bis(2-flurobenzylidene piperidin-4-one) and DAP compounds are shown. DAP-F(p) and DAP-CF3(p) are 3,5-diarylidenyl piperidones containing para-fluoro substitutions on the phenyl groups. DAP-F(p)-NOH and DAP-CF3(p)-NOH contain an N-hydroxy-pyrroline moiety covalently linked to the N-terminus of the piperidone ring. (DAP figures reproduced with permission from Free Radical Biology and Medicine/Elsevier, reference # 46).