Fig. 9

FTO sensitizes ovarian cancer cells to cDDP and PPAR inhibitor via RP5-991G20.1/hsa-miR-1976/MEIS1 axis. Relative level of FTO (A), relative lncRNA level of RP5-991G20.1 (B), relative miRNA level of hsa-miR-1976 (C) and relative mRNA level of MEIS1 (D) were detected in A2780 cells transfected with si-FTO. Relative level of FTO (E), relative lncRNA level of RP5-991G20.1 (F), relative miRNA level of hsa-miR-1976 (G) and relative mRNA level of MEIS1 (H) were detected in tumour specimens from ovarian cancer patients with PFS > 6 months vs. PFS < 6 months. Cell colonies assay (I) of A2780 cells transfected with si-FTO were shown