Table 5 The subgroup analysis for the primary pregnant outcomes according to study design
Fixed/Random model | Sensitivity analysis | |||||||
|---|---|---|---|---|---|---|---|---|
Outcome | Numbers of participants | Subgroup analysis | RR(95%CI) | I2 (%) | Heterogeneity (P) | RR(95% CI) | I2 (%) | Heterogeneity (P) |
Implantation | 2807 | RCT | 0.89(0.63, 1.24) | 55.8 | 0.132 | 0.89(0.63,1.24) | 55.8 | 0.132 |
Case-controlled | 1.16(1.03, 1.32) | 65.0 | 0.004 | 1.21(1.05,1.39) | 63.6 | 0.007 | ||
Total | 1.12(1.00, 1.24) | 63.7 | 0.002 | 1.14(1.01,1.29) | 64.5 | 0.003 | ||
Clinical pregnancy | 3640 | RCT | 1.04(0.81,1.34) | 51.4 | 0.103 | 1.04(0.81,1.34) | 51.4 | 0.103 |
Case-controlled | 1.24(1.11,1.38) | 60.4 | 0.002 | 1.28(1.13,1.44) | 57.9 | 0.006 | ||
Total | 1.19(1.08, 1.32) | 59.0 | 0.001 | 1.22(1.10,1.36) | 58.5 | 0.002 | ||
Miscarriage | 2091 | RCT | 0.83(0.53,1.29) | 59.3 | 0.061 | 0.79(0.32,1.95) | 57.4 | 0.071 |
Case-controlled | 0.81(0.63,1.06) | 0.0 | 0.709 | 0.87(0.66,1.15) | 0.0 | 0.896 | ||
Total | 0.82(0.65, 1.02) | 2.2 | 0.428 | 0.89(0.70,1.31) | 0.0 | 0.619 | ||