Fig. 1

High HOXB2 expression correlates with platinum resistance and poor prognosis in patients with OV. A. The target gene HOXB2 was chosen from the intersection of the four gene clusters, as follows: a. Genes with higher expression in the TCGA OV dataset compared with the GTEx non-tumor dataset. b. Genes with predictive functions of prognosis based on TCGA OV dataset. c. Genes with higher expression in platinum-resistant OV cell lines than in platinum-sensitive cell lines in GSE140996. d. Genes with higher expression in platinum-resistant samples than in platinum-sensitive samples in GSE41500. B. Detail mRNA level of HOXB2 in GSE41500, GSE140996, TCGA (n = 428), and GTEx (n = 88) datasets. A two-tailed P-value was calculated using an unpaired t-test. C. The overall survival curve for patients with OV was based on the expression of HOXB2 in the TCGA dataset. A two-sided log-rank test was performed to calculate the statistical significance. D. Representative images (left) and statistical analysis (right) of IHC staining for HOXB2 in chemotherapy-resistant samples and chemotherapy-sensitive samples. Scale bar, 200 μm. The chi-square test was used for the analysis. E. Representative images (left) and statistical analysis (right) of IHC staining for HOXB2 in 117 OV TMA samples with different stages. Scale bar, 200 μm. The P-value was calculated with the chi-square test. *P < 0.05, **P < 0.01, ***P < 0.001, ***P < 0.0001