Fig. 4

Reduction of HOXB2 sensitizes OV cells to cisplatin in vivo.A. Subcutaneous xenografts transplanted with A2780/DDP shNC and shHOXB2 cells in Balb/c nude mice treated with PBS or 5 mg/kg CDDP. Scale bar, 1 cm. B. Statistical analysis of the weight and size of subcutaneous xenografts from the different groups. The P-value between the two groups was calculated using an unpaired t-test. C–D. Represent images (left) and statistical analysis (right) of IHC staining for Ki67 and TUNEL assay in subcutaneous xenografts. The P-value between the two groups was calculated using an unpaired t-test. Scale bar, 200 μm. E. Results of CISH with DANCR probes in subcutaneous xenografts. *P < 0.05, **P < 0.01, ***P < 0.001, ***P < 0.0001