Fig. 5
From: HOXB2 promotes cisplatin resistance by upregulating lncRNA DANCR in ovarian cancer
HOXB2 modulates the expression of ABC transporters and Erk activity. A. Functional analysis of the differentially expressed genes from the RNA-Seq results of OV8 shNC cells and shHOXB2 cells based on KEGG pathways. B. Relative mRNA levels of ABC transporters in OV8 shNC and shHOXB2 cells. C. Gene set enrichment analysis was performed to compare the OV8 shNC and shHOXB2 cells. NES, Normalized enrichment score. D. qPCR results showing the expression levels of ABC transporters of shNC, shHOXB2-1, and shHOXB2-2 cells. E. Correlation analysis of HOXB2 with ABCA1, ABCC3, and ABCG1 based on the TCGA database. r, Pearson’s correlation coefficient. F. WB analysis of ABCA1 and ABCG1 expression in shNC, shHOXB2-1, and shHOXB2-2 cells. G. GSEA result of OV8 shNC cells and shHOXB2 cells. H. WB results of p-MAPK42/44 (Erk1/2) and total Erk levels in shNC, shHOXB2-1, and shHOXB2-2 cells. *P < 0.05, **P < 0.01, ***P < 0.001, ***P < 0.0001