Fig. 5

SK treatment reduces tumorigenesis of SKOV3 cells in nude mice and reduces M2 macrophage infiltration. SKOV3 cells were subcutaneously injected into CB-17 SCID mice to generate xenograft tumors, followed by OC exo or SK OC exo treatment. A, growth rate within 4 weeks and weight at week 4 of xenograft tumors in mice; B, Ki67 expression in the xenograft tumor tissues examined by IHC; C, expression of CD163 and CD206 in the xenograft tumor tissues examined by IHC; D, GAL3 expression in the xenograft tumor tissues examined by IHC; E, nuclear and cytoplastic β-catenin levels in macrophages isolated from xenograft tumors determined by WB analysis. In each group, n = 6. Differences were compared by the one-way or two-way ANOVA. *p < 0.05