Table 1 Hypomethylation in endometrial tissues compared the endometriosis

HOXB1

homeotic genes B1

3.749

0.386

0.813

0

Important growth and development regulatory genes regulator of retinoic acid

response elements (RAREs)

MCC

membrane compartment of Can1

3.709

0.288

2.587

0

one cytoplasm membrane microdomain regulating metabolism, cellular morphogenesis, signaling cascades, and mRNA degradation.

TMEM101

transmembrane protein 101

3.695

0.297

2.629

0

upregulation and increase the expression of NF-κB in ovary cancer.

CASS4

Homo sapiens Cas scaffolding protein family

member 4

3.624

0.515

1.530

0.004

Possible docking protein which may play a role for tyrosine-kinase-based signaling related to cell adhesion. Regulates FAK

activity, focal adhesion integrity, and cell

spreading.

BST2

bone marrow stromal cell antigen 2

3.612

0.450

1.713

0

Regulating Type-I interferon and interleukin-6 generation

FABP3

Fatty Acid Binding Protein 3

3.150

0.298

2.098

0.004

During the early stages of pregnancy, upregulating cell growth and proliferation in uterine endometrium

FAIM2

Fas Apoptotic Inhibitory Molecule

3.052

0.317

2.376

0.012

specifically protecting cells from Fas-induced apoptosis

SHANK2

SH3 and multiple ankyrin

repeat domains protein

3.051

0.353

2.140

0.004

A protein-coding gene relating to autism

TCF21

Transcription Factor 21

3.030

0.433

1.563

0.008

augmenting steroidogenic factor (SF) 1 and

estrogen receptor β (ERβ)

PRDM1

positive regulatory domain 1

2.983

0.431

1.269

0.012

increased IL-10 + Th17 cells are significantly

MIR365A

MicroRNA 365a

2.974

0.378

0.842

0.016

involving posttranscriptional modulation of genes via regulating mRNA stabilization and translation

FOXP1

Forkhead Box P1

2.849

0.443

1.492

0.02

activating Wnt/β-cateninsignaling pathway

in endometriosis

LOC339803

LOC339803

2.841

0.199

2.358

0.028

Enhancing HCC invasion and migration via miR-30a-5p/ SNAIL1.

In human atherosclerotic lesions, serve as potential biomarkers for lesion hypoxia.

ZNF311

Zinc Finger Protein311

2.833

0.330

1.838

0

upregulated in grade-depended glioma patients of adverse outcome

RNASE1

Ribonuclease A Family Member 1

2.773

0.364

1.027

0.008

a key player in regulation of vascular homeostasis

LYPLAL1

Long non coding RNA lysophospholipase

-like l

2.771

0.206

1.338

0.008

Long non coding RNA lysophospholipase-like2

PAX2

Paired Box Homeotic Gene 2

2.670

0.291

1.741

0.036

Its mutations contribute to optical nerve glioma and kidney dysplasia

NUP210L

Nucleoporin 210

2.663

0.328

0.868

0.036

Encoding a membrane-spanning glycoprotein which participates in formation of nuclear pore complex

SLC1A2

Solute Carrier Family 1 Member 2

2.657

0.329

1.856

0.04

Encoding a solute transporter protein

MX2

MX Dynamin Like GTPase 2

2.646

0.252

1.770

0.04

Encoding a protein of dynamin and GTPases families, with nuclear and cytoplasmic forms.

SVIL

Supervillin

2.632

0.369

0.863

0.04

Encoded product contributes to myosin II assembly and disintegration of focal adhesions.

TERC

Telomerase RNA Component

2.614

0.227

1.500

0.024

Encoding telomerase.

PROCA1

Protein Interacting With Cyclin A1

2.588

0.259

1.982

0.032

Enables cyclin binding activity. Predicted to be

involved in arachidonic acid secretion and

phospholipid metabolic process

ARHGAP25

Rho GTPase Activating Protein 25

2.577

0.300

1.637

0.004

Encoding negative regulators of Rho GTPases.

DAW1

Dynein Assembly Factor With WD

Repeats 1

2.569

0.226

0.679

0.02

Maybe the upstream of some processes, including cerebrospinal fluid circulation; determination of left/right symmetry; and outer dynein arm assembly.

MAGI2-AS3

MAGI2 Antisense RNA 3

2.563

0.264

1.783

0.048

An RNA Gene, affiliated with the

lncRNA class. Diseases associated with MAGI2-AS3 include Nephrotic Syndrome,

Type 15 and Breast Cancer.

TNFSF13B

TNF Superfamily Member 13b

2.488

0.179

2.000

0.036

modulating B cells proliferation and

differentiation.

HOXA2

Homeobox A2

2.3473

0.330

0.864

0.008

Encoding a DNA-binding

transcription factor governing morphogenesis,

and differentiation.

SGIP1

SH3GL Interacting Endocytic Adaptor 1

2.103

0.196

1.691

0.016

May involve in clathrin-mediated endocytosis and energy homeostasis.

ASCL2

Achaete-Scute Family BHLH

Transcription

Factor 2

2.028

0.257

0.838

0

related pathways are Embryonic and Induced

Pluripotent Stem Cells and Lineage-specific

Markers and Human Early Embryo Development.

EPM2AIP1

EPM2A Interacting Protein 1

2.013

0.133

1.007

0.028

MLH1 and EPM2AIP1 genes share a common

promoter whose methylation has been shown to affect both genes.

UBD

Ubiquitin D

1.818

0.140

1.309

0.004

Encoded protein participates in aggresomes formation, mitotic regulation, and dendritic cell maturation.

RNF39

RING finger protein 39

1.6484

0.201

0.535

0.012

Its variants were linked to viral diseases and autoimmune diseases.

TBX3

T-Box Transcription Factor 3

1.567

0.272

0.756

0.004

Regulating developmental processes.

PON1

Paraoxonase 1

1.390

0.180

0.537

0.016

Displaying lactonase and ester hydrolase activity.

ZIC1

Zic Family Member 1

1.157

0.138

0.750

0.032

Encoding a C2H2-type zinc finger proteins.