Table 2 Hypermethylation in endometrial tissues compared the endometriosis
From: DNA methylation profiles of ovarian cysts resemble ovarian tissues but not endometrial tissues
Gene Symbol | Gene name | DMR value (Endometrial vs. Cyst) | Delta_beta | Log2 Fold Change Ratio | P value | Function |
|---|---|---|---|---|---|---|
SHF | Src Homology 2 Domain Containing F | -2.107 | -0,172 | -1.249 | 0.016 | May enable phosphotyrosine residue binding activation, and participate in apoptosis. |
ESR1 | Estrogen Receptor 1 | -2.177 | -0.296 | -1.520 | 0.016 | Encoding estrogen receptor, vital for hormone binding, and transcriptional activation. |
ESR2 | Estrogen Receptor 2 | -2.280 | 0.036 | Encoding the estrogen receptor 2. | ||
RBM24 | RNA Binding Motif Protein 24 | -2.414 | -0.249 | -1.816 | 0.036 | Involved in several processes, including negative regulation of cytoplasmic translation, and regulation of mRNA metabolic process. |
LMO7DN | LIM Domain 7 downstream neighbour | -2.487 | -0.334 | -0.728 | 0.02 | Involved in lung cancer prognosis. |
ZC3H12D | Zinc Finger CCCH-Type Containing 12D | -2.541 | -0.327 | -1.454 | 0.02 | Predicted to enable endoribonuclease activity and mRNA binding activity, and negatively modulate G1/S transition and cell growth |
CACNB2 | Calcium Voltage-Gated Channel Auxiliary Subunit Beta 2 | -2.550 | -0.234 | -1.729 | 0.02 | Encoding a subunit of voltage-dependent calcium channel proteins. |
C17orf107(CHRNE) | Cholinergic Receptor Nicotinic Epsilon Subunit | -2.563 | -0.197 | -2.101 | 0.048 | After binding acetylcholine, AChR undergoes an alteration in conformation opening an ionotransduction channels across the plasma membrane |
HAND2-AS1 | HAND2 Antisense RNA 1 | -2.605 | -0.383 | -1.315 | 0.044 | Predicted to be involved in positive regulation of gene expression, and possess a positive effect on cardiac right ventricle morphogenesis. |
PEMT | Phosphatidylethanolamine N- Methyltransferase | -2.800 | -0.346 | -0.731 | 0.028 | Converting phosphatidylethanolamine to phosphatidylcholine by sequential methylation. |
ZNF22 | Zinc Finger Protein22 | -2.837 | -0.259 | -1.282 | 0.012 | Modulating cell migration, adhesion, and cycle. |
STRA6 | Signaling Receptor And Transporter Of Retinol STRA6 | -3.033 | -0.430 | -1.369 | 0 | Encoding a membrane protein responsible for retinol metabolism. |
LINC00460 | Long Intergenic Non-Protein Coding RNA 460 | -3.090 | -0.351 | -1.068 | 0.004 | play vital roles in the pathogenesis, tumorigenesis, and angiogenesis of cancers. |
LRMDA | Leucine Rich Melanocyte Differentiation Associated | -3.270 | -0.442 | -1.282 | 0.004 | This gene encodes a leucine-rich repeat protein. |
EMX2OS | EMX2OS | -3.272 | -0.445 | -1.943 | 0 | Modulating ovarian cancer cells through miR-654-3p/AKT3/PD-L1. |
RNF19A | RING finger protein 19 A | -3.461 | -0.448 | -1.526 | 0 | Interacting with alpha synuclein in neurons. |
HOXC4 | Homeobox C4 | -3.463 | -0.435 | -2.510 | 0 | Related to immunodeficiency with Hyper-Igm, and lymphoma. |
TFAMP1 | Transcription Factor A, Mitochondrial Pseudogene 1 | -3.641 | -0.391 | -0.901 | 0.004 | Encoding a mitochondrial transcription factor. |
FMN1 | Formin 1 | -4.035 | -0.407 | -2.890 | 0 | Modulating development of adhesion junction and linear actin polymerization. |