Table 3 The differentially methylated genes were consistent with the reported expression changes in endometriosis
From: DNA methylation profiles of ovarian cysts resemble ovarian tissues but not endometrial tissues
Gene Symbol | Gene name | DMR value (Endometrial vs. Cyst) | Delta_beta | Log2 Fold Change Ratio | P value | Function | |||||
|---|---|---|---|---|---|---|---|---|---|---|---|
Hypomethylation | |||||||||||
BST2 | bone marrow stromal cell antigen 2 | 3.612 | 0.450 | 1.713 | 0 | Regulating type-I interferon and interleukin-6 generation Modulating embryo-maternal immune. | |||||
TCF21 | Transcription Factor 21 | 3.030 | 0.433 | 1.563 | 0.008 | Interacting with upstream stimulatory factor 2, transactivating SF-1 and Erβ promoters, and modulating estrogen pathway and fibrosis in endometriosis. | |||||
FOXP1 | Forkhead Box P1 | 2.849 | 0.443 | 1.492 | 0.02 | FOXP1 activating Wnt/β-cateninsignaling pathway in endometriosis.Its knockdown reverted endometrium cell phenotypes. | |||||
TNFSF13B | TNF Superfamily Member 13b | 2.488 | 0.179 | 2.000 | 0.036 | Modulating B cells proliferation and differentiation. Increased in serum of endometriosis subjects. | |||||
Hypermethylation | |||||||||||
ESR1 | Estrogen Receptor 1 | -2.177 | -0.296 | -1.520 | 0.016 | Encoding estrogen receptor, vital for hormone binding, and transcriptional activation. | |||||
STRA6 | Signaling Receptor And Transporter Of Retinol STRA6 | -3.033 | -0.430 | -1.369 | 0 | Vital for retinol binding protein, the retinol uptake into cells. Downregulating STRA6 enhanced endogenous estradiol synthesis. | |||||
PEMT | Phosphatidylethanolamine N- Methyltransferase | -2.800 | -0.259 | -1.282 | 0.028 | Converting phosphatidylethanolamine to phosphatidylcholine by sequential methylation. Its polymorphism may induce infertility of endometriosis women. | |||||