Skip to main content

Table 3 The effects of licorice supplementation on obesity indices, blood biomarkers, and insulin resistance in overweight/obese women with PCOS

From: Effects of licorice extract in combination with a low-calorie diet on obesity indices, glycemic indices, and lipid profiles in overweight/obese women with polycystic ovary syndrome (PCOS): a randomized, double-blind, placebo-controlled trial

Variables

Intervention group

(n = 33)

Control group

(n = 33)

*P-value

**P-value

***P-value

Body weight (kg)

     

Baseline

88.84 ± 4.83

87.94 ± 4.12

0.54

  

After intervention

82.60 ± 4.30

86.09 ± 10.71

< 0.001

< 0.001

< 0.001

****P-value

< 0.001

0.41

   

Body mass index (kg/m2)

     

Baseline

30.67 ± 0.53

30.72 ± 0.48

0.43

  

After intervention

29.03 ± 0.60

30.73 ± 0.47

< 0.001

< 0.001

< 0.001

****P-value

< 0.001

0.25

   

Percent body fat (%)

     

Baseline

30.66 ± 1.47

29.76 ± 0.75

0.01

  

After intervention

28.21 ± 0.65

29.75 ± 0.75

< 0.001

< 0.001

< 0.001

****P-value

< 0.001

0.97

   

Triglyceride (mg/dl)

     

Baseline

144.98 ± 39.80

140.00 ± 41.74

0.62

  

After intervention

91.00 ± 23.63

140.60 ± 41.96

< 0.001

< 0.001

< 0.001

****P-value

< 0.001

0.16

   

Total cholesterol (mg/dl)

     

Baseline

194.88 ± 38.99

176.24 ± 40.45

0.06

  

After intervention

149.00 ± 34.12

180.94 ± 41.55

0.001

< 0.001

< 0.001

****P-value

< 0.001

0.21

   

Low-density lipoprotein- cholesterol (mg/dl)

     

Baseline

121.13 ± 39.67

100.97 ± 41.20

0.05

  

After intervention

81.13 ± 32.83

105.60 ± 41.34

0.01

< 0.001

0.01

****P-value

< 0.001

0.71

   

High-density lipoprotein- cholesterol (mg/dl)

     

Baseline

44.72 ± 3.76

47.27 ± 3.01

0.01

  

After intervention

50.18 ± 2.12

47.21 ± 3.13

< 0.001

< 0.001

< 0.001

****P-value

< 0.001

0.85

   

Fasting blood sugar (mg/dl)

     

Baseline

100.03 ± 12.98

93.48 ± 11.92

0.06

  

After intervention

74.00 ± 4.33

94.03 ± 11.942

< 0.001

< 0.001

< 0.001

****P-value

< 0.001

0.07

   

Insulin (µIU/ml)

     

Baseline

9.57 ± 4.14

11.06 ± 0.07

0.15

  

After intervention

6.68 ± 3.21

11.06 ± 4.20

< 0.001

< 0.001

0.01

****P-value

< 0.001

0.98

   

HOMA-IR

     

Baseline

2.38 ± 1.11

2.54 ± 1.03

0.55

  

After intervention

1.23 ± 0.63

2.55 ± 1.02

< 0.001

< 0.001

< 0.001

****P-value

< 0.001

0.16

   

HOMA-B

     

Baseline

31.11 ± 14.82

40.13 ± 14.82

0.03

  

After intervention

28.92 ± 14.87

39.92 ± 18.64

0.01

0.15

0.49

****P-value

< 0.001

0.09

   
  1. − Abbreviations: HOMA-IR: homeostatic model assessment for insulin resistance; HOMA-B: HOMA of β-cell function.
  2. − Values are expressed as means ± SD.
  3. − * Independent sample t-test or Mann-Whitney test were used for comparison of quantitative variables between the two groups.
  4. − **Analysis of covariance (ANCOVA) was used for comparisons between the two groups post-intervention after adjusting for baseline values.
  5. − ***Analysis of covariance (ANCOVA) was used for comparisons between the two groups post-intervention after adjusting for baseline values plus other confounders such as age, weight changes (except for body weight, body mass index, and percent body fat), and physical activity changes.
  6. − ****Paired t-test or Wilcoxon Signed Ranks test were used to compare within group difference from baseline to post-intervention period.
  7. − P < 0.05 was considered statistically significant.
Back to article page

Journal of Ovarian Research

ISSN: 1757-2215

Contact us