Fig. 2

Functional role of CENP-O in regulating ovarian cancer cell growth and apoptosis in vitro. (A) Fluorescent image of SK-OV-3 and ES-2 cells migration area. (B) The proliferation rate/multiplication factor of shCtrl and shCENPO group of two cell lines determined by Celigo. (C) Caspase3/7 activity and (D) MTT assays were performed to determine the proliferation of ovarian cancer cells transduced with the CENP-O shRNA lentivirus ( doubling time of SK-OV-3: 20–48 h, ES-2: 28–36 h). (Significant differences between two groups were analyzed using Student’s t-test. Significance was indicated as follows: p ≤ 0.05 (*); p ≤ 0.01 (**); p ≤ 0.001 (***); p ≤ 0.0001 (****))