Fig. 4

Effect of BM-MSCs transplantation on mRNA expression of IGF-1/HPG axis of the POI rats (A – F). A. hypothalamic mRNA IGF-1, B. hypothalamic mRNA Kiss-1, C. hypothalamic mRNA Kiss-r1, D. hypothalamic mRNA GnIH-1, E. hypothalamic mRNA GnRH, and F. hypothalamic mRNA GnRHr. The values represent the average of 6 to 8 rats in each group ± SEM *p < 0.05, **p < 0.01, ****p < 0.0001