Fig. 3

Construction of risk signature in the TCGA cohort. (A) Univariate Cox regression analysis was performed for each gene related to sialylation, resulting in the identification of six genes with a significance level of P < 0.05. (B-C) LASSO regression was then conducted on these six genes associated with overall survival (OS), and parameter selection was carried out through cross-validation. (D) The sample distribution is based on the risk score. The survival status of each sample is displayed on the left for the low-risk population and on the right for the high-risk group. (E) Survival status for each sample (low risk population: left, high-risk group: right, respectively). (F) Kaplan-Meier plots demonstrate the overall survival of samples categorized into high- and low-risk groups. (G) ROC curves showcase the predictive capability of the risk score. (H) 1-year, 2-year and 3-year survival rates were plotted on calibration curves. (I) Decision curve analysis was also performed to assess the clinical utility of the risk model