Table 2 Nanoparticle-mediated therapies in the treatment of ovarian cancer
From: Nanotechnology for boosting ovarian cancer immunotherapy
Nanoparticle | Functional moieties | Type of therapy | Preclinical studies | References |
|---|---|---|---|---|
TPD@TB/KBU2046 | KBU2046 (small molecule inhibitor), TB (photodynamic-AIEgens) and TPD- TMTP1 (a targeting peptide | Photodynamic therapy | in vitro and in vivo (ovarian tumor models) studies | [85] |
PPI dendrimer-based nanoplatforms | Phthalocyanine (Pc) as the near-infrared (NIR) photosensitizer (functionalized with PEG and LHRH peptide) and siRNA as a DJ-1 gene suppressor | Photodynamic therapy | in vitro and in vivo (subcutaneous xenografts of A2780/AD cancer cells) studies | [87] |
Hy-loaded PLA Nanoparticles | Hypericin (Hy), a natural photosensitizer (PS), and polylactic acid (PLA) | Photodynamic therapy | in vitro phototoxicity assay | [88] |
NLC- verteporfin | Verteporfin, a photosensitizer and nanostructured lipid carriers | Photodynamic therapy | in vitro cytotoxicity assay and in vivo (ovarian tumor models) studies | [89] |
Photo-immuno-conjugate-associating-liposome (PICAL) | Benzoporphyrin derivative monoacid A (BPD), the Cetuximab antibody, and Preformed Plain Liposome (PPL) | Photodynamic therapy | in vitro phototoxicity assay | [90] |
FBPD Nanoparticles | NIR laser responsive nanoparticles (PLGA-PEG-FA encapsulating Bi2S3, PFP, and Dox | Photothermal therapy | in vitro and in vivo studies | [91] |
Biodegradable photoresponsive Nanoparticles | Poly(lactic-co-glycolic nanoparticles, carboplatin drug (CP), and the near-infrared (NIR) photosensitizer indocyanine green (ICG) | Chemo phototherapy (Combination of phototherapies and chemotherapy) | in vitro studies | [92] |