Fig. 3
From: Neoadjuvant chemotherapy induces phenotypic mast cell changes in high grade serous ovarian cancer
Intratumoral histamine is upregulated following chemotherapy exposure (A) Representative immunofluorescence images of histamine expression in 20 matched pre- and post-NACT tumors and corresponding secondary only, negative control taken at a 10x objective. (B) Mean intensity (pixels) and (C) Integrated optical density of histamine in pre- versus post-NACT HGSOC tumors. Statistically significant differences determined by Student T-test. NACT, neoadjuvant chemotherapy, HGSOC, high grade serous ovarian cancer, *p < 0.05, as indicated