Fig. 4
From: Neoadjuvant chemotherapy induces phenotypic mast cell changes in high grade serous ovarian cancer
Tryptase +/ CPA3 + mast cells are upregulated following chemotherapy exposure (A) Representative immunofluorescence images of Tryptase, CPA3 expression in 29 matched pre- and post-NACT tumors and corresponding secondary only, negative control taken at a 40x objective. (B) Average number of Tryptase + /CPA3 + cells per field in matched pre-and post-NACT exposed HGSOC tumors. Statistically significant differences determined by Student T-test. NACT, neoadjuvant chemotherapy, HGSOC, high grade serous ovarian cancer, ***p < 0.0005, as indicated