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Fig. 5 | Journal of Ovarian Research

Fig. 5

From: Nicotinamide mononucleotide improves the ovarian reserve of POI by inhibiting NLRP3-mediated pyroptosis of ovarian granulosa cells

Fig. 5

NMN can increase NAD+ levels and restore the expression of SIRT2 in POI rats. A) Determination of NAD+ content; B) Protein expression of SIRT2 in the ovaries was determined using western blot analysis, β-tubulin served as the loading control; C) Relative protein expression of SIRT2 was quantified by ImageJ software and normalized to 𝛽-tubulin (n = 3 rats per group); D) The mRNA levels of SIRT2 analyzed by qRT-PCR, GAPDH was used as control; E) Immunohistochemical analysis of SIRT2 expression in the ovaries; data are presented as mean ± standard deviation (SD). *p < 0.05, **p < 0.01

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Journal of Ovarian Research

ISSN: 1757-2215

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