Table 3 Comparisons of screening performances between traditional and optimized joint screening strategies for ovarian cancer

Traditional strategy 1 (positive screen defined as only any positive TVU)

 Positive

55.6

(49.2–61.8)

Ref.

51.4

(50.8–51.9)

Ref.

48.7

(48.1–49.3)

Ref.

7.0

1.0

(0.85–1.19)

99.2

(99.1–99.4)

 Negative

 Total

Traditional strategy 2 (positive screen defined as any positive TVU and CA125 above diagnostic criteria)

 Positive

60.8

(54.4–66.8)

< 0.001

50.1

(49.5–50.7)

< 0.001

50.0

(49.4–50.6)

< 0.001

10.9

1.1

(0.91–1.25)

99.3

(99.2–99.4)

 Negative

 Total

Optimized strategy 1 (positive screen defined as any positive TVU and CA125 above optimal cut-off value)

 Positive

79.6

(74.0-84.3)

< 0.001

32.2

(31.6–32.7)

< 0.001

67.9

(67.4–68.5)

< 0.001

11.8

1.0

(0.89–1.18)

99.4

(99.3–99.6)

 Negative

 Total

Optimized strategy 2 (based on strategy 1 and excluding CA125_LP as positive screen)

 Positive

76.0

(70.1–81.1)

< 0.001

38.3

(37.7–38.9)

< 0.001

61.8

(61.3–62.4)

< 0.001

14.3

1.1

(0.93–1.25)

99.4

(99.3–99.6)

 Negative

 Total

Optimized strategy 3 (based on strategy 2 and excluding negative RelVel in either CA125_SP or CA125_GP as positive screen)

 Positive

64.4

(58.1–70.3)

< 0.001

48.8

(48.2–49.4)

< 0.001

51.3

(50.8–51.9)

< 0.001

13.2

1.1

(0.94–1.29)

99.4

(99.2–99.5)

 Negative

 Total