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Table 4 Comparison of ART cycle stimulation parameters, embryology, and clinical reproductive outcomes between AST and placebo groups

From: Astaxanthin improves assisted reproductive technology outcomes in poor ovarian responders through alleviating oxidative stress, inflammation, and apoptosis: a randomized clinical trial

Variables

AST (n = 26)

Placebo (n = 25)

P-value#

Total gonadotrophin doses (IU)

5648.08 ± 623.816

5862.00 ± 653.00

0.207

rFSH doses (IU)

2423.08 ± 232.155

2520.00 ± 243.02

0.149

HMG dose (IU)

3225.00 ± 453.486

3342.00 ± 427.61

0.299

Stimulation duration (days)

10.77 ± 1.03

11.20 ± 1.08

0.149

Number of follicles >16mm

4.42 ± 1.33

3.96 ± 1.13

0.186

Retrieved oocytes (n)

4.38 ± 1.35

3.36 ± 1.03

0.003*

GV (n)

0.73 ± 0.60

0.88 ± 0.60

0.188

MI (n)

0.27 ± 0.45

0.32 ± 0.47

0.723

MII (n)

3.38 ± 1.44

2.16 ± 0.89

0.004*

Oocyte maturity rate (MII %)

75.64 ± 17.03

66.00 ± 22.02

0.089

Fertilization rate (%)

89.74 ± 15.33

90.33 ± 16.25

0.973

Frozen embryos (n)

2.73 ± 1.61

1.80 ± 0.86

0.037*

High-quality embryos (n)

2.62 ± 1.41

1.64 ± 0.75

0.014*

Transferred embryos (n)

1.73 ± 0.66

1.68 ± 0.74

0.776

Canceled ET, n (%)

2/26 (7.7%)

2/25 (8.0%)

0.682

Chemical pregnancy rate, n (%)

9/24 (37.5%)

8/23 (34.8%)

0.995

Clinical pregnancy rate, n (%)

5/24 (20.8%)

4/23 (17.4%)

0.695

  1. AST Astaxanthin group, rFSH recombinant follicle-stimulating hormone, HMG human menopausal gonadotropin, GV germinal vesicle, MI metaphase I, MII metaphase II, ET embryo transfer, n Number. Table values represent either mean ±SD or number (percentages). #Logistic regression adjusted for age, AMH, and AFC as confounding variables. Statistical significance is denoted by aP-value of less than 0.05 (*P < 0.05)