Fig. 3

LDHA in follicular fluid extracellular vesicles is a direct target of miR-34a-5p. A The expression of miR-34a-5p in extracellular vesicles was analyzed by miRNA-seq. B The expression of miR-34a-5p in the follicular fluid extracellular vesicles was analyzed by qPCR. C The expression of LDHA in the follicular fluid extracellular vesicles was analyzed by qPCR. D Correlation between LDHA (Y-axis) and miR-34a-5p (X-axis) expression changes in the follicular fluid extracellular vesicles. E miR-34a-5p regulates the LDHA expression by binding to the 3’-UTR of LDHA mRNA. G: The inhibition rate of miR-34a-5p on the LDHA luciferase activity (**p < 0.01)