Fig. 2

CPI-613 inhibits growth and improves overall survival in ovarian cancer xenografts. A OVCAR3, (C) CaOV3 and (E) F2 intraperitoneal xenografts (n = 8) were treated with 2.5 mg/kg body weight of CPI-613 thrice a week in corn oil and observed for survival as described in the Methods section. Control groups were treated with corn oil alone. The significance of the Kaplan Meier graph was estimated by Gehan-Breslow-Wilcoxon test. MS = median survival in days. Bar graph shows average tumor weights isolated from the (B) OVCAR3, (D) CaOV3 and (F) F2 mouse models (n = 8). Representative immunohistochemistry images (400x) showing Ki67 stain in (G) OVCAR3, (H) CaOV3 and (I) F2 xenografts. J, K, L Bar graphs show the Ki-index calculated from n = 5 images per group at high-power field (HPF). *p ≤ 0.05, **p ≤ 0.01, ***p ≤ 0.001 untreated control (C) compared to CPI-613