Fig. 4

In vivo imaging of subcutaneous OC tumors and biodistribution of cetuximab-Cy7 probe. (A) BLI imaging was used to detect SKOV3-Luc OC tumor cells at 4, 24, 48, 96, 144, 192, and 264 h post-injection of cetuximab-Cy7. In vivo NIRF imaging of mice post-injection of cetuximab-Cy7 in (B) the lateral position and (C) the ventral position at the same timepoints. The control groups including PBS, free Cy7 dye and mouse isotype IgG-Cy7 were also used in our previous work [22]. The corresponding images in the control groups in Fig. 4A and B were reprinted with permission from reference 22. OC: ovarian cancer; BLI: bioluminescent; Cetuximab-Cy7: cetuximab-cyanine7; IgG-Cy7: immunoglobulin G-cyanine7; NIRF: near-infrared fluorescence; PBS: phosphate-buffered saline