Fig. 1
From: Searching for the ‘X’ factor: investigating the genetics of primary ovarian insufficiency
Visual representation of proposed primary ovarian insufficiency (POI)-linked regions on the X chromosome. Black and grey regions represent heterochromatin and white regions represent euchromatin. Pink overlay represents regions identified as being liked to POI in humans, while blue overlay represents genes identified through mouse studies. (A) Critical regions proposed based on early studies of chromosomal rearrangements. (B) Locations of candidate genes proposed by X chromosome copy number variation analysis by Yatsenko et al. 2019 [5]. (C) Locations of genes found to have variants associated with cases of POI, and genes found to cause POI in knockout mouse models. Figure created with BioRender