Fig. 2

Co-expression network of module eigengenes and clinical traits within TCGA-OV cohort. Twenty-three network coexpression module eigengenes (MEs) (ranking from largest number of module members to smallest) were identified: M1 to M23 for 389 patient samples. A Module Trait Relationships Heatmap; The correlation between the summary of gene expression profiles, module eigengenes (rows) and clinical traits (columns) is shown. The cells in the heatmap contain the bicor correlation coefficient with red denoting a positive correlation and blue a negative correlation. Strength of association is measured in color intensity. P values relate to significance of correlation between module eigengenes and clinical traits. B Hierarchical clustering of module eigengenes depicts branches within the dendrogram, grouping eigengenes with positive correlations. Row and columns are paired within the heatmap, correlating to one module eigengene labeled by color. The blue represents low adjacency, vindictive of a negative correlation, while the red shows high adjacency or a positive correlation. The meta-modules are depicted through squares of red color placed diagonally