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Fig. 3 | Journal of Ovarian Research

Fig. 3

From: Subtype-specific analysis of gene co-expression networks and immune cell profiling reveals high grade serous ovarian cancer subtype linkage to variable immune microenvironment

Fig. 3

iGRAPH Module Network and STRING Analysis of Hub Genes in HGSOC Molecular Subtypes. A, C, E iGraph network plots displaying the hub genes from three immune-mediated co-expression modules (M3, M5, M18) in HGSOC for 389 patient samples. The size of each node represents the top 10% of hub genes based on kME values, and edge thickness reflects the strength of co-expression between genes. The network highlights central genes driving each module’s function, revealing distinct molecular signatures across subtypes. B, D, F STRING analysis of each module’s top 10 hub genes illustrates predicted protein–protein interactions. The nodes represent individual proteins, while the edges reflect the confidence of interactions (line thickness indicates interaction confidence). Enrichment analysis within STRING revealed key pathways related to immune response, cellular differentiation, and extracellular matrix remodeling, which are linked to immunoreactive and mesenchymal subtypes

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Journal of Ovarian Research

ISSN: 1757-2215

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