Fig. 4

Immune Cell Enrichment and Composition in HGSOC. A Heatmap depicting the enrichment of immune cell markers across HGSOC subtypes (n = 389; additional details in Additional File 5). Rows represent module membership, and columns represent specific immune cell types. Colors indicate the significance of the relative enrichment scores present on the scale, with purple denoting higher enrichment and yellow indicating lower enrichment. Box plots representing the fractions of eight different immune cell types across HGSOC subtypes within the bulk tumor expression (B) across the whole dataset and (C) subtype-specific, as calculated by EPIC. Each box plot shows each cell fraction’s median, interquartile range, and outliers for each cell fraction. Statistical significance is indicated by asterisks using the following scale (*p < 0.05, **p < 0.01, ***p < 0.001)