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Table 1 Ontology enrichment analysis of WGCNA modules of interest

From: Subtype-specific analysis of gene co-expression networks and immune cell profiling reveals high grade serous ovarian cancer subtype linkage to variable immune microenvironment

Module

ANOVA p

Top Biological processes

GO- Elite FET FDR

Red (M6)

7.53 e -62

Animal Organ Morphogenesis

0.000108

Nervous System Process

0.000119

Action Potential

0.000171

Pink (M8)

5.10 e -46

System Development

3.05e-28

Multicellular Organism Development

2.32e-23

Anatomical Structure Development

3.85e-21

Brown (M3)

2.20 e -77

Immune System Process

2.01e-223

Immune Response

9.80e-210

Defense Response

6.50e-166

Green (M5)

1.88 e -78

Multicellular Organismal Process

7.32e-69

System Development

9.31e-67

Circulatory System Development

2.77e-63

Tan (M12)

8.89 e -20

No significant biological processes were identified

NA

Midnight blue (M15)

2.75 e -13

Multicellular Organismal Process

0.00128

Regulation Of Hormone Levels

0.00731

Developmental Process

0.01086

Grey70 (M17)

1.73 e -12

No significant biological processes were identified

NA

Light green (M18)

6.24 e -28

Adaptive Immune Response

1.70 e-163

Immune Response

1.04e-121

Immune System Process

4.70 e-107

  1. A Fisher Exact Test (one-tailed) FDC correction was used to detect overlap significance amongst GO lists of gene symbols and module membership for enrichment p < 0.05 and 5 genes minimum per ontology