Fig. 6
From: Single-cell sequencing reveals PTX3 involvement in ovarian cancer metastasis
Association between PTX3 and immune infiltration in OC. (A) Correlation between PTX3 expression and infiltration levels of B cells, CD8 + T cells, CD4 + T cells, macrophage M0, myeloid dendritic cells, and CAFs in OC, available from the TIMER2.0 database. (B) Correlation between PTX3 expression and chemokines and chemokine receptors in OC provided in TISIDB database. (C) UMAP plot of all HGSOC advanced primary tumor samples, with different colors used to divide the subgroups. (D) Heatmap depicting the expression levels of selected marker genes in major cell subgroups. Rows represent genes, and columns represent clusters. (E) Heatmap showing the number of ligand-receptor pair interactions among cell subtypes, with tumor cells grouped by PTX3 expression as either High or Low. (F) Dot plot showing the expression of selected chemokine-related ligands or receptors across cell subtypes. The color of the dots represents expression levels, the size of the dots indicates the percentage of expression, and lines depict known ligand-receptor interactions