Fig. 1

SB-HD enhanced the cytotoxicity of DDP for OC cells and inhibited colony formation. (A–B) Cell viability of SKOV3 and OVCAR3 cells after treatment with indicated concentrations of SB-HD at different mass ratios (4:1, 2:1, 1:1, 1:2, 1:4). (C) Time-dependent curves of cell viability by SB- HD at 6 h, 12 h, 24 h, 48 h, and 72 h. (D–F) Cell viability of SKOV3 and OVCAR3 cells after combination treatment of SB-HD and DDP. (G–H) Clone formation of SKOV3 and OVCAR3 cells treated with SB-HD and DDP (*p<0.05, **p<0.01, ***p<0.001vs control;#p<0.05, ##p<0.01, ###p<0.001vs DDP; n = 3–6)