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Fig. 4 | Journal of Ovarian Research

Fig. 4

From: Scutellaria barbata D.Don and Hedyotis diffusa Willd herb pair combined with cisplatin synergistically inhibits ovarian cancer progression through modulating oxidative stress via NRF2-FTH1 autophagic degradation pathway

Fig. 4

Combination treatment inhibited xenograft tumor growth in vivo. (A) Experimental set-up. (B) Representative image of xenografted tumors in mice. (C) Anatomical view of mouse tumors. (D) The average weight of the tumors. (E) Tumor growth curve. (F) Body weight curves of mice. (G) Kidney index, Liver index and Spleen index. (H) HE staining of the heart, liver, spleen, lung and kidney (scale bar = 100 μm). (I) AST, ALT, BUN, and Cre levels of mice after treatment. (J) HE staining of tumors (scale bar = 100 μm). (K) IHC analysis of Ki67 expression in tumor tissues (*p<0.05, **p<0.01, ***p<0.001vs control;#p<0.05, ##p<0.01, ###p<0.001vs DDP; n = 3–6)

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Journal of Ovarian Research

ISSN: 1757-2215

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