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Table 1 General patient characteristics and clinical pregnancy outcomes after a fresh cycle in the NOR and DOR groups

From: Bile acids in follicular fluid: potential new therapeutic targets and predictive markers for women with diminished ovarian reserve

Variable

NOR (n = 91)

DOR (n = 91)

P value

Age, years

33.76 ± 0.36

34.26 ± 0.38

0.229

Body mass index, kg/m2

22.23 ± 0.35

22.30 ± 0.33

0.612

Infertility diagnosis

  

1.000

 Primary infertility

60 (65.9)

60 (65.9)

 

 Secondary infertility

31 (34.1)

31 (34.1)

 

Duration of infertility, years

3.25 ± 0.30

3.91 ± 0.32

0.057

Male factor infertility

70 (76.9)

71 (78.0)

0.859

Baseline FSH, mIU/mL

6.13 ± 0.20

10.05 ± 0.47

< 0.001*

Baseline AMH, ng/mL

3.38 ± 0.17

0.61 ± 0.03

< 0.001*

Antral follicle count

14.32 ± 0.61

3.98 ± 0.28

< 0.001*

Baseline LH, IU/L

3.62 ± 0.20

3.46 ± 0.17

0.592

Baseline E2, pmol/L

107.30 ± 12.81

161.07 ± 27.05

0.018*

Baseline P, ng/mL

1.23 ± 0.08

2.95 ± 1.56

0.579

Fertilization method

  

0.006*

 IVF

41 (45.0)

56 (61.5)

 

 ICSI

44 (48.4)

35 (38.5)

 

 IVF + ICSI

6 (6.6)

0 (0)

 

Duration of stimulation, days

10.35 ± 0.17

10.23 ± 0.27

0.572

Gonadotropins dose, IU

2523.43 ± 85.56

2992.92 ± 148.68

0.034*

LH on hCG day, IU/L

38.89 ± 36.51

20.28 ± 17.05

0.012*

E2 on hCG day, pmol/L

10986.32 ± 647.84

3739.22 ± 298.61

< 0.001*

P on hCG day, ng/mL

2.45 ± 0.12

2.18 ± 0.38

< 0.001*

Endometrial thickness, mm

10.39 ± 0.16

9.35 ± 0.23

0.004*

No. of oocytes retrieved

12.04 ± 0.58

3.79 ± 0.26

< 0.001*

Normal fertilization rate

0.67 ± 0.02

0.62 ± 0.04

0.928

Cleavage rate

0.98 ± 0.01

0.94 ± 0.02

0.420

Available embryo rate

0.38 ± 0.03

0.41 ± 0.04

0.890

High quality embryo rate

0.47 ± 0.03

0.46 ± 0.04

0.850

No. of embryos transferred

  

< 0.001*

 1

2/47 (4.3)

20/45 (44.4)

 

 2

45/47 (95.7)

25/45 (55.6)

 

Type of embryo transferred

  

0.144

 Cleavage embryo

47/47 (100.0)

43/45 (95.6)

 

 Blastocyst

0/47 (0.0)

2/45 (4.4)

 

Biochemical pregnancy

25/47 (53.2)

22/45 (48.9)

0.835

Clinical pregnancy

25/47 (53.2)

21/45 (46.7)

0.677

Pregnancy loss

3/25 (12.0)

4/21 (19.0)

0.686

Live birth

  

0.381

 Singleton live birth

17/47 (36.2)

14/45 (31.1)

 

 Multiple live births

5/47 (10.6)

3/45 (6.7)

 
  1. Note Continuous data are reported as the mean ± standard deviation. Categorical data are reported as n (%). The Mann‒Whitney U test was used to analyze continuous data, and the chi‒square test or Fisher’s exact test was used to analyze categorical data. NOR = normal ovarian reserve; DOR = diminished ovarian reserve. * P < 0.05
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Journal of Ovarian Research

ISSN: 1757-2215

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