Fig. 5

RNA sequencing revealed a significant upregulation of cellular energy metabolism and synthesis-related pathways in the sempervirine/control group. (A) Volcano plot of upregulated and downregulated genes; (B) Number of differential gene expression between sempervirine and control groups; with mTOR notably upregulated in the sempervirine/control group. (C) Bubble chart of z-score from GO enrichment analysis. (D) Bubble chart of z-score from KEGG enrichment analysis