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Fig. 6 | Journal of Ovarian Research

Fig. 6

From: Sempervirine inhibits proliferation, invasion and metastasis of ovarian cancer cells and induces ultrastructural changes in vivo

Fig. 6

Sempervirine significantly decreased apelin and CD34. (A) qPCR analysis showed sempervirine significantly decreased apelin and CD34 mRNA levels in a dose-dependent manner in SKOV3 cells. (B) In tumor tissues, sempervirine dose-dependently blocked elevated expression of apelin and CD34 mRNA compared to control. (C) Western blot analysis demonstrated increased apelin and CD34 protein expression in SKOV3 cells following sempervirine treatment. (D) Similarly, sempervirine dose-dependently prevented increased apelin and CD34 protein levels in tumor tissues. The inhibitory effect of high dose sempervirine was comparable to positive control 5-Fu

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Journal of Ovarian Research

ISSN: 1757-2215

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