Table 2 DHEA compared to control for [IVF]
Patient or population: patients with [IVF] | |||||
|---|---|---|---|---|---|
Settings: | |||||
Intervention: DHEA | |||||
Comparison: Control | |||||
Outcomes | Illustrative comparative risksa (95% CI) | Relative effect (95% CI) | No of Participants (studies) | Quality of the evidence (GRADE) | |
Assumed risk | Corresponding risk | ||||
Control | DHEA | ||||
Live birth/ongoing pregnancy rate | Study population | OR 1.33 (0.98 to 1.82) | 1217 (10 studies) | ⊕⊕⊝⊝ low 1,2 | |
141 per 1000 | 179 per 1000 (139 to 230) | ||||
Moderate | |||||
127 per 1000 | 162 per 1000 (125 to 209) | ||||
CPR | Study population | OR 1.34 (1.08 to 1.67) | 1949 (15 studies) | ⊕⊕⊝⊝ low 1,2 | |
196 per 1000 | 246 per 1000 (208 to 289) | ||||
Moderate | |||||
160 per 1000 | 203 per 1000 (171 to 241) | ||||
MR | Study population | OR 0.83 (0.45 to 1.53) | 391 (6 studies) | ⊕⊕⊝⊝ low 1,2 | |
139 per 1000 | 118 per 1000 (68 to 198) | ||||
Moderate | |||||
123 per 1000 | 104 per 1000 (59 to 177) | ||||
EMT | The mean emt in the intervention groups was 0.93 higher (0.27 to 1.6 higher) | 559 (7 studies) | ⊕⊕⊝⊝ low 1,3 | ||
Number of retrieved oocytes | The mean number of retrieved oocytes in the intervention groups was 0.73 higher (0.36 to 1.1 higher) | 1829 (15 studies) | ⊕⊕⊝⊝ low 1,3 | ||
Number of MII oocytes | The mean number of mii oocytes in the intervention groups was 0.56 higher (0.06 lower to 1.18 higher) | 842 (8 studies) | ⊕⊝⊝⊝ very low 1,3,4 | ||
Number of oocytes fertilized | The mean number of oocytes fertilized in the intervention groups was 0.48 higher (0.1 to 0.87 higher) | 1077 (8 studies) | ⊕⊕⊝⊝ low 1,3 | ||
Number of transferred embryos | The mean number of transferred embryos in the intervention groups was 0.27 higher (0.09 to 0.46 higher) | 1020 (11 studies) | ⊕⊝⊝⊝ very low 1,2,3 | ||
Number of good quality embryos | The mean number of good quality embryos in the intervention groups was 0.65 higher (0.27 to 1.03 higher) | 1063 (8 studies) | ⊕⊕⊝⊝ low 1,3 | ||