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Table 1 Details of the studies included in the current study

From: Association of TCF7L2 genetic variants rs12255372 and rs7903146 with the polycystic ovary syndrome risk: systematic review and meta-analysis

Author (year)

Ethnicity

Study type and Outcome

Genotype for rs7903146

Genotype for rs12255372

Cases

Controls

Cases

Controls

CC

CT

TT

N

CC

CT

TT

N

GG

GT

TT

N

GG

GT

TT

N

Barber et al. (2007)

European British/Irish

CC/NA

177

151

30

358

600

539

104

1243

-

-

-

-

-

-

-

-

Christopoulos et al. (2008)

European (Greece)

CC/WA

43

108

32

183

52

76

20

148

-

-

-

-

-

-

-

-

Xu et al. (2010)

Asian (China)

CC/NA

261

61

4

326

232

56

2

290

-

-

-

-

-

-

-

-

Kim et al. (2012)

Asian (Korea)

CC/NA

350

27

0

377

357

29

0

386

372

5

0

377

383

3

0

386

Vcela´k et al. (2012)

European (Czech Republic)

CC/NA

178

127

24

329

204

147

24

375

189

119

2

310

207

146

23

376

Ramos et al. (2013)

Caucasians (Brazil)

CC/NA

104

55

33

192

51

36

10

97

-

-

-

-

-

-

-

-

A. Ben-Salem et al. (2014)

Tunisian (Tunisia)

CC/NA

37

51

30

118

46

69

32

147

45

42

31

118

44

60

34

138

Reddy et al. (2016)

Asia (India)

CC/NA

122

96

22

240

103

87

16

206

146

92

10

248

132

69

8

209

Taskin et al. (2021)

Turkish (Turkey)

CC/NA

21

21

6

48

22

10

8

40

-

-

-

-

-

-

-

-

Rashid et al. (2022&23)*

Asia (India)

CC/NA/SA

97

21

2

120

100

18

2

120

44

73

3

120

65

55

0

120

  1. N: Sample size
  2. For the column “Study type and Outcome: CC represents case-control study design, NA, WA and SA represent no association, weak association and statistical association of the studied genetic variation with the PCOS risk respectively. *Rashid et al has reported association of rs12255372 variant with the PCOS risk
  3. ‘-’ represents data not available