Table 4 Associations between 1-unit increment of cytokines and time to recurrence
≤ 1 year | > 1 year | |||
|---|---|---|---|---|
Biomarkers (pg/mL) | aHR (95% CI) | P | aHR (95% CI) | P |
GROα | ||||
Baseline | 1.022 (0.987–1.058) | 0.219 | 0.997 (0.960–1.035) | 0.862 |
Post | 1.005 (0.971–1.039) | 0.784 | 0.997 (0.970–1.026) | 0.850 |
Change | 0.965 (0.917–1.015) | 0.165 | 0.992 (0.916–1.075) | 0.852 |
IL-6 | ||||
Baseline | 1.016 (0.987–1.046) | 0.283 | 1.654 (0.616–4.440) | 0.318 |
Post | 0.982 (0.886–1.089) | 0.737 | 1.031 (0.936–1.136) | 0.531 |
Change | 0.977 (0.945–1.010) | 0.177 | 0.884 (0.715–1.094) | 0.257 |
IL-8 | ||||
Baseline | 1.377 (0.948–1.999) | 0.093 | 0.781 (0.356–1.713) | 0.538 |
Post | 1.334 (0.879–2.023) | 0.176 | 0.795 (0.406–1.560) | 0.506 |
Change | 0.886 (0.621–1.263) | 0.503 | 0.908 (0.305–2.701) | 0.862 |
IL-12 | ||||
Baseline | 1.042 (0.988–1.100) | 0.132 | 0.984 (0.943–1.026) | 0.451 |
Post | 1.058 (0.994–1.126) | 0.079 | 0.983 (0.936–1.033) | 0.503 |
Change | 1.012 (0.955–1.072) | 0.690 | 1.013 (0.926–1.109) | 0.776 |
IL-13 | ||||
Baseline | 0.990 (0.950–1.031) | 0.615 | 1.029 (0.992–1.067) | 0.123 |
Post | 1.021 (0.992–1.050) | 0.153 | 1.022 (0.989–1.056) | 0.199 |
Change | 1.022 (0.997–1.047) | 0.090 | 0.995 (0.950–1.041) | 0.815 |
IL-27 | ||||
Baseline | 1.001 (1.000–1.002) | 0.201 | 1.000 (0.999–1.002) | 0.622 |
Post | 1.001 (1.000–1.002) | 0.234 | 0.998 (0.996–1.000) | 0.137 |
Change | 1.000 (0.998–1.001) | 0.856 | 0.999 (0.997–1.000) | 0.069 |
IP-10 | ||||
Baseline | 1.001 (0.998–1.005) | 0.392 | 0.993 (0.979–1.008) | 0.343 |
Post | 0.999 (0.987–1.012) | 0.912 | 1.029 (0.991–1.068) | 0.139 |
Change | 0.999 (0.996–1.002) | 0.414 | 1.013 (0.997–1.030) | 0.110 |
MCP-1 | ||||
Baseline | 1.010 (1.000–1.021) | 0.050 | 0.998 (0.984–1.013) | 0.827 |
Post | 1.001 (0.998–1.004) | 0.534 | 1.013 (1.001–1.025) | 0.032 |
Change | 1.000 (0.996–1.004) | 0.943 | 1.023 (1.003–1.043) | 0.025 |
MDC | ||||
Baseline | 1.003 (0.996–1.011) | 0.372 | 0.994 (0.987–1.001) | 0.114 |
Post | 0.992 (0.979–1.004) | 0.188 | 0.995 (0.985–1.004) | 0.280 |
Change | 0.978 (0.960–0.996) | 0.019 | 1.002 (0.996–1.007) | 0.576 |