Fig. 3

Wxzz increased serum irisin levels in DHEA and HFD-induced PCOS combined IR mice. Serum irisin levels were significantly negatively correlated with body weight, FINS, HOMA-IR, T, LH, and negatively correlated with LH/FSH. (A) Quantitative analysis of serum irisin levels in mice (n = 6 mice per group). Data were analyzed by one-way ANOVA and Tukey’s multiple comparisons post hoc test and are expressed as mean ± SEM. (B) Correlation analysis of irisin with body weight, metabolism, and hormone levels (n = 6 mice per group). Data were analyzed using Pearson’s correlation analysis. *P < 0.05. **P < 0.001. ***P < 0.0001