Fig. 1

Integrated scRNA-seq analysis of tumor tissues from ovarian cancer patients. (A) t-SNE visualization of 32,129 single cells passed quality controls, colored by six ovarian cancer patients. (B) The unsupervised clustering of 32,129 cells. (C) t-SNE visualization of cell types annotated by classical gene markers. (D) Expression levels of known markers for specific cell types overlaid on the t-SNE representation. (E) Heatmap for gene expression levels of top ten cell-type-specific genes. (F) Comparing the exosome scores between tumor and non-tumor cells. (G) Bar plot showing the enriched signaling pathways in tumor cells with high exosome scores