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Fig. 7 | Journal of Ovarian Research

Fig. 7

From: Identification of exosome-related SERPINB1 as a novel predictor for tumor immune microenvironment and clinical outcomes in ovarian cancer

Fig. 7

Validation of the regulatory role of SERPINB1 in CD8 + T cells functions. (A) Representative images uncovering the expression of SERPINB1 and CD8 in ovarian cancer tumor tissues. (B) Correlation between SERPINB1 expression and CD8 score in ovarian cancer. (C) Differential expression of SERPINB1 in immune-desert and immune-enrich tumor samples. ***P < 0.001. (D) Transmission electron microscopy. Transmission electron micrographs of purified exosomes secreted from SKOV3 cells and SKOV3 cells treated with recombinant SERPINB1 protein. Scale bar, 100 nm. (E) Nanoparticle analysis. Concentration and size distribution of nano-sized particles in exosome suspension. (F) Western blot analysis of exosomes isolated from SKOV3 cells and SKOV3 cells treated with recombinant SERPINB1. (G) Activation levels of T cells treated with exosomes isolated from SKOV3 cells and SKOV3 cells treated with recombinant SERPINB1 protein

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Journal of Ovarian Research

ISSN: 1757-2215

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