Table 3 The top 10 targets rank in cytoHubba
No. | Betweenness | Closeness | Degree | DMNC | EPC | MCC | MNC |
|---|---|---|---|---|---|---|---|
1 | TLR4 | TLR4 | TLR4 | CXCR1 | TLR4 | TLR4 | TLR4 |
2 | GSK3B | MMP9 | MMP9 | CXCR2 | PTGS2 | PTGS2 | MMP9 |
3 | PTGS2 | PTGS2 | PTGS2 | TLR8 | MMP9 | MMP9 | PTGS2 |
4 | MMP9 | GSK3B | GSK3B | CCR1 | MCL1 | MCL1 | JUN |
5 | MCL1 | MCL1 | JUN | MCL1 | JUN | JUN | GSK3B |
6 | PFKFB3 | JUN | MCL1 | STAT6 | GSK3B | GSK3B | MCL1 |
7 | TLR8 | BCL2A1 | CCR1 | BCL2A1 | BCL2A1 | CCR1 | CCR1 |
8 | JUN | CCR1 | TLR8 | PTGS2 | CCR1 | CXCR2 | STAT6 |
9 | NAMPT | STAT6 | STAT6 | JUN | STAT6 | TLR8 | TLR8 |
10 | BCL2A1 | TLR8 | BCL2A1 | MMP9 | CXCR2 | STAT6 | BCL2A1 |
11 | STAT6 | CXCR2 | CXCR2 | PTAFR | TLR8 | BCL2A1 | CXCR2 |
12 | CCR1 | NAMPT | NAMPT | NAMPT | NAMPT | CXCR1 | NAMPT |
13 | PYGL | CXCR1 | CXCR1 | TLR4 | CXCR1 | NAMPT | CXCR1 |
14 | CXCR2 | PFKFB3 | PFKFB3 | GSK3B | PTAFR | PTAFR | CREBBP |
15 | CREBBP | PTAFR | CREBBP | CREBBP | CREBBP | CREBBP | PTAFR |
16 | CDK5R1 | CREBBP | PTAFR | CDK5R1 | PFKFB3 | PFKFB3 | CDK5R1 |
17 | CXCR1 | PYGL | CDK5R1 | PFKFB3 | CDK5R1 | CDK5R1 | PFKFB3 |
18 | MPEG1 | CDK5R1 | FKBP5 | FKBP5 | FKBP5 | FKBP5 | FKBP5 |
19 | CYP1B1 | FKBP5 | PYGL | MPEG1 | PYGL | PYGL | MPEG1 |
20 | EGLN1 | CYP1B1 | MPEG1 | CYP1B1 | CYP1B1 | MPEG1 | CYP1B1 |
21 | PTAFR | MPEG1 | CYP1B1 | EGLN1 | MPEG1 | CYP1B1 | EGLN1 |
22 | FKBP5 | EGLN1 | EGLN1 | PYGL | EGLN1 | EGLN1 | PYGL |