Fig. 3

Conjoint analyses of up-regulated DEmiRNAs in FF-EVs and down-regulated DEGs in oocytes. (A) The Venn diagram demonstrated the overlapping genes of the up-regulated DEmiRNAs’ target genes and the down-regulated DEGs. (B) The co-expression network between the up-regulated DEmiRNAs and down-regulated DEGs. (C) The bar chart of GO enrichment analysis of overlapping genes. BP: Biological process, CC: Cell component, MF: Molecular function. (D) The bar chart showed KEGG pathway analysis of overlapping genes. The length of bars in (C) and (D) represented the number of overlapping genes that were involved. The color of bars indicated p values of pathways. (E) The protein-protein interaction network of overlapping genes. The size and color of node in (B) and (E) represented the number of interacting genes. Large sizes and dark colors indicated more genes interacted