Fig. 8
From: miR-34a-5p modulation of polycystic ovary syndrome via targeting the NOTCH signaling pathway
Overview of the role of miR-34a-5p in GCs. miR-34a-5p is elevated in serum and FF in PCOS. Elevated miR-34a-5p negatively regulates JAG1 protein and also affects Notch pathway-related proteins, which upregulates the expression of pro-apoptosis-related proteins and ultimately affects GCs proliferation