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Table 2 Baseline and reproductive characteristics of the participants in different causes of infertility groups

From: Association of age at menarche and different causes of infertility: a retrospective study of 7634 women undergoing assisted reproductive technology

 

Reference group

(N = 6379)

PCOS

(N = 635)

P value

Endometriosis

(N = 151)

P value

DOR

(N = 175)

P value

Unexplained infertility

(N = 303)

P value

Age at time of study (years)

30.00 (27.00, 35.00)

28.00 (26.00, 31.00)

< 0.001***

31.00 (29.00, 35.00)

0.034*

33.00 (27.00, 38.00)

0.001**

31.00 (28.00, 35.00)

0.007**

BMI at time of study (kg/m^2)

22.89 (20.81, 25.44)

24.57 (21.80, 27.71)

< 0.001***

22.48 (20.59, 24.55)

0.063

22.56 (20.31, 25.49)

0.133

22.94 (20.82, 25.46)

0.708

Age at menarche (years)

14.00 (13.00, 15.00)

14.00 (13.00, 15.00)

0.012*

14.00 (13.00, 15.00)

0.016*

13.00 (13.00, 14.00)

< 0.001***

14.00 (13.00, 15.00)

0.801

AAM category n (%)

 ≤12

831 (13.0)

72 (11.3)

0.039*

30 (19.9)

0.179

34 (19.4)

< 0.001***

41 (13.5)

0.977

 13

1511 (23.7)

148 (23.3)

 

37 (24.5)

 

71 (40.6)

 

72 (23.8)

 

 14

1785 (28.0)

153 (24.1)

 

41 (27.2)

 

28 (16.0)

 

85 (28.1)

 

 15

1220 (19.1)

132 (20.8)

 

25 (16.6)

 

20 (11.4)

 

58 (19.1)

 

 16

697 (10.9)

83 (13.1)

 

13 (8.6)

 

14 (8.0)

 

29 (9.6)

 

 ≥ 17

335 (5.2)

46 (7.2)

 

5 (3.3)

 

8 (4.6)

 

18 (5.9)

 

Educational level n (%)

         

 Primary school and below

366 (5.7)

29 (4.6)

0.022*

5 (3.3)

0.004**

5 (2.9)

0.050

13 (4.3)

0.157

 Middle school

2245 (35.2)

259 (40.8)

 

38 (25.2)

 

56 (32.0)

 

97 (32.0)

 

 High school or technical secondary school

1418 (22.2)

128 (20.1)

 

28 (18.5)

 

36 (20.5)

 

63 (20.7)

 

 Junior college degree

1089 (17.1)

116 (18.2)

 

37 (24.5)

 

27 (15.4)

 

59 (19.4)

 

 Bachelor’s degree

1068 (16.7)

92 (14.5)

 

36 (23.8)

 

44 (25.1)

 

65 (21.5)

 

 Master’s degree and above

193 (3.0)

11 (1.7)

 

7 (4.6)

 

7 (4.0)

 

6 (2.0)

 

Irregular menstruation n (%)

      

 No

5557 (87.1)

67 (10.6)

< 0.001***

142 (94.0)

0.012*

142 (81.1)

0.021*

257 (84.8)

0.246

 Yes

822 (12.9)

568 (89.4)

 

9 (6.0)

 

33 (18.9)

 

46 (15.2)

 

Dysmenorrhea n (%)

         

 No

5607 (87.9)

572 (90.1)

0.106

103 (68.2)

< 0.001***

159 (90.9)

0.235

261 (86.1)

0.360

 Yes

772 (12.1)

63 (9.9)

 

48 (31.8)

 

16 (9.1)

 

42 (13.9)

 

Family history (Whether mother had infertility) n (%)

      

 No

6281 (98.5)

627 (98.7)

0.586

149 (98.7)

0.834

171 (97.7)

0.429

296 (97.7)

0.290

 Yes

98 (1.5)

8 (1.3)

 

2 (1.3)

 

4 (2.3)

 

7 (2.3)

 

Type of infertility n (%)

         

 Primary infertility

3513 (55.1)

486 (76.5)

< 0.001***

90 (59.6)

0.268

99 (56.6)

0.694

190 (62.7)

0.009**

 Secondary infertility

2866 (44.9)

149 (23.4)

 

61 (40.3)

 

76 (43.4)

 

113 (37.3)

 

Number of previous abortions

0 (0, 1)

0 (0, 0)

0.012*

0 (0, 1)

0.620

0 (0, 1)

0.078

0 (0, 1)

0.599

Hormone levels

         

 FSH (IU/L)

6.54 (5.59, 7.76)

5.83 (5.06, 6.73)

< 0.001***

6.86 (5.92, 8.15)

0.024*

11.66 (8.58, 17.16)

< 0.001***

6.68 (5.50, 7.95)

0.379

 LH (IU/L)

4.69 (3.54, 6.12)

8.02 (5.06, 11.71)

< 0.001***

4.53 (3.55, 5.62)

0.435

5.85 (3.65, 8.85)

< 0.001***

4.51 (3.44, 6.17)

0.552

 E2 (pg/mL)

33.80 (25.80, 44.30)

36.70 (28.10, 46.60)

< 0.001***

36.50 (29.20, 48.00)

0.002**

35.50 (21.10, 56.90)

0.581

35.1 (26.00, 45.70)

0.221

 P (ng/mL)

0.53 (0.38, 0.70)

0.62 (0.42, 0.82)

< 0.001***

0.50 (0.39, 0.66)

0.351

0.55 (0.41, 0.69)

0.465

0.53 (0.37, 0.73)

0.782

 PRL (ng/mL)

15.43 (11.40, 20.63)

15.97 (11.32, 21.08)

0.388

16.90 (12.00, 23.20)

0.008**

13.69 (9.95, 19.17)

0.002**

14.87 (10.70, 19.26)

0.068

 T (ng/dL)

22.84 (16.29, 30.70)

37.27 (26.89, 47.91)

< 0.001***

22.16 (15.43, 28.74)

0.124

21.07 (14.23, 26.90)

0.001**

23.90 (15.46, 31.71)

0.733

 TSH (µIU/mL)

2.13 (1.54, 2.90)

2.26 (1.60, 2.94)

0.024*

2.08 (1.41, 2.91)

0.281

2.23 (1.66, 3.02)

0.312

2.18 (1.49, 2.96)

0.508

 AMH (ng/mL)

3.37 (1.76, 5.77)

9.41 (6.16, 13.68)

< 0.001***

2.62 (1.34, 4.70)

0.001**

0.44 (0.10, 0.88)

< 0.001***

3.14 (1.71, 5.34)

0.335

  1. Notes: * Case group vs. Reference group, P < 0.05; ** Case group vs. Reference group, P < 0.01; *** Case group vs. Reference group, P < 0.001
  2. Abbreviations: PCOS, polycystic ovary syndrome; DOR, diminished ovarian reserve; BMI, body mass index; AAM, age at menarche; FSH, follicle stimulating hormone; LH, luteinizing hormone; P, progesterone; E2, estradiol; PRL, prolactin; T, testosterone; TSH, thyroid stimulating hormone; AMH, antimullerian hormone
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Journal of Ovarian Research

ISSN: 1757-2215

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