Table 4 Mediating role of metabolites in the causal relationship between GM and OC
Exposure | Mediation | Outcome | Mediated effect | Mediated proportion | Pvalue | Direct effect | All effect |
|---|---|---|---|---|---|---|---|
genus.unknowngenus.id.2071 | 1-linoleoyl-2-linolenoyl-GPC (18:2/18:3) levels | OC | -0.008(-0.027, 0.010) | 6.7% (21.3%, -7.9%) | 0.369 | -0.116 | -0.125 |
genus.unknowngenus.id.2041 | N-acetylputrescine to (N(1) + N(8))-acetylspermidine ratio | OC | 0.006(-0.009, 0.021) | -5.3% (8.3%, -18.9%) | 0.445 | -0.117 | -0.111 |
genus.unknowngenus.id.2041 | N6-acetyllysine levels | OC | 0.012(-0.010, 0.034) | -10.5% (9.3%, -30.3%) | 0.300 | -0.123 | -0.111 |
genus.unknowngenus.id.2041 | Alpha-hydroxyisocaproate levels | OC | -0.013(-0.031, 0.004) | 11.9% (27.9%, -4.0%) | 0.142 | -0.098 | -0.111 |
genus.Prevotella9.id.11,183 | X-24,951 levels | OC | -0.019(-0.041, 0.004) | 15.2% (33.6%, -3.3%) | 0.107 | -0.104 | -0.122 |
genus.Prevotella9.id.11,183 | X-23,678 levels | OC | 0.017(-0.007, 0.041) | -13.8% (5.9%, -33.6%) | 0.170 | -0.139 | -0.122 |
genus.Prevotella9.id.11,183 | Linolenoylcarnitine (C18:3) levels | OC | 0.018(-0.002, 0.039) | -14.9% (2.0%, -31.9%) | 0.084 | -0.140 | -0.122 |
genus.FamilyXIIIAD3011group.id.11,293 | Histidine to trans-urocanate ratio | OC | 0.023(-0.015, 0.061) | -14.9% (9.6%, -39.4%) | 0.234 | -0.177 | -0.154 |
genus.FamilyXIIIAD3011group.id.11,293 | Pseudouridine levels | OC | 0.018(-0.012, 0.049) | -11.8% (7.9%, -31.5%) | 0.239 | -0.172 | -0.154 |
phylum.Euryarchaeota.id.55 | Oleoyl-linoleoyl-glycerol (18:1 to 18:2) [2] to linoleoyl-arachidonoyl-glycerol (18:2 to 20:4) [1] ratio | OC | -0.006(-0.016, 0.004) | 6.8% (17.9%, -4.4%) | 0.234 | -0.084 | -0.090 |
genus.FamilyXIIIAD3011group.id.11,293 | 1-palmitoyl-2-stearoyl-gpc (16:0/18:0) levels | OC | -0.026(-0.080, 0.028) | 16.6% (51.5%, -18.4%) | 0.352 | -0.129 | -0.154 |
genus.FamilyXIIIAD3011group.id.11,293 | Trimethylamine n-oxide levels | OC | -0.018(-0.045, 0.009) | 11.7% (29.1%, -5.8%) | 0.191 | -0.136 | -0.154 |
genus.FamilyXIIIAD3011group.id.11,293 | Imidazole propionate levels | OC | 0.015(-0.020, 0.050) | -9.7% (12.8%, -32.1%) | 0.399 | -0.169 | -0.154 |
genus.FamilyXIIIAD3011group.id.11,293 | 1-linoleoyl-gpc (18:2) levels | OC | 0.016(-0.012, 0.044) | -10.2% (8.0%, -28.4%) | 0.272 | -0.170 | -0.154 |
genus.Escherichia.Shigella.id.3504 | Salicylate to oxalate (ethanedioate) ratio | OC | 0.014(-0.008, 0.037) | -10.6% (6.3%, -27.5%) | 0.218 | -0.147 | -0.133 |
genus.Escherichia.Shigella.id.3504 | X-12,221 levels | OC | 0.021(-0.013, 0.054) | -15.4% (10.0%, -40.7%) | 0.235 | -0.154 | -0.133 |
genus.Escherichia.Shigella.id.3504 | Pseudouridine levels | OC | -0.015(-0.035, 0.006) | 10.9% (26.1%, -4.4%) | 0.161 | -0.119 | -0.133 |
genus.Escherichia.Shigella.id.3504 | Dimethylglycine levels | OC | 0.013(-0.010, 0.036) | -9.7% (7.5%, -26.9%) | 0.269 | -0.146 | -0.133 |
genus.Escherichia.Shigella.id.3504 | 3-amino-2-piperidone levels | OC | 0.013(-0.008, 0.034) | -9.6% (6.4%, -25.5%) | 0.239 | -0.146 | -0.133 |
genus.Escherichia.Shigella.id.3504 | N-acetylserine levels | OC | -0.010(-0.029, 0.008) | 7.8% (21.6%, -6.0%) | 0.266 | -0.123 | -0.133 |
phylum.Euryarchaeota.id.55 | 1-palmitoyl-2-arachidonoyl-gpc (16:0/20:4n6) levels | OC | -0.007(-0.019, 0.006) | 7.4% (21.0%, -6.2%) | 0.286 | -0.083 | -0.090 |
genus.ChristensenellaceaeR.7group.id.11,283 | Gamma-CEHC glucuronide levels | OC | -0.013(-0.065, 0.039) | -5.8% (-28.7%, 17.2%) | 0.623 | 0.241 | 0.228 |
family.Victivallaceae.id.2255 | Linoleoyl-arachidonoyl-glycerol (18:2/20:4) [1] levels | OC | -0.006(-0.015, 0.003) | -6.9% (-16.6%, 2.8%) | 0.163 | 0.099 | 0.093 |
phylum.Euryarchaeota.id.55 | 1-stearoyl-2-arachidonoyl-gpc (18:0/20:4) levels | OC | -0.006(-0.018, 0.006) | 6.2% (19.5%, -7.2%) | 0.366 | -0.084 | -0.090 |
phylum.Euryarchaeota.id.55 | Pseudouridine levels | OC | 0.009(-0.001, 0.020) | -10.3% (1.1%, -21.6%) | 0.076 | -0.099 | -0.090 |
phylum.Euryarchaeota.id.55 | Linoleoyl-arachidonoyl-glycerol (18:2/20:4) [1] levels | OC | -0.008(-0.018, 0.003) | 8.6% (20.3%, -3.1%) | 0.148 | -0.082 | -0.090 |
phylum.Euryarchaeota.id.55 | N6-acetyllysine levels | OC | 0.007(-0.005, 0.020) | -8.1% (5.9%, -22.0%) | 0.257 | -0.097 | -0.090 |
genus.unknowngenus.id.2071 | X-16,087 levels | OC | 0.012(-0.014, 0.039) | -10.0% (11.3%, -31.2%) | 0.358 | -0.137 | -0.125 |
genus.unknowngenus.id.2071 | 3-amino-2-piperidone levels | OC | 0.014(-0.009, 0.038) | -11.3% (7.4%, -30.0%) | 0.234 | -0.139 | -0.125 |
phylum.Euryarchaeota.id.55 | Cholesterol to linoleoyl-arachidonoyl-glycerol (18:2 to 20:4) [1] ratio | OC | -0.006(-0.016, 0.003) | 6.9% (17.3%, -3.4%) | 0.188 | -0.084 | -0.090 |