Table 5 Mediating role of metabolites in the causal relationship between GM and EC
Exposure | Mediation | Outcome | Mediated effect | Mediated proportion | Pvalue | Direct effect | All effect |
|---|---|---|---|---|---|---|---|
genus.RuminococcaceaeUCG014.id.11,371 | X-11,858 levels | EC | 0.016(-0.013, 0.046) | -11.5% (9.4%, -32.5%) | 0.280 | -0.157 | -0.141 |
genus.RuminococcaceaeUCG014.id.11,371 | Cytosine levels | EC | 0.024(-0.007, 0.056) | -17.3% (4.9%, -39.6%) | 0.126 | -0.165 | -0.141 |
genus.RuminococcaceaeUCG014.id.11,371 | Trans 3,4-methyleneheptanoate levels | EC | -0.022(-0.057, 0.012) | 15.8% (40.3%, -8.7%) | 0.207 | -0.119 | -0.141 |
genus.RuminococcaceaeUCG014.id.11,371 | Carboxyethyl-gaba levels | EC | 0.016(-0.008, 0.040) | -11.2% (5.8%, -28.2%) | 0.197 | -0.157 | -0.141 |
genus.Dorea.id.1997 | X-24,307 levels | EC | -0.026(-0.071, 0.018) | 12.8% (34.4%, -8.8%) | 0.245 | -0.179 | -0.205 |
genus.Dorea.id.1997 | X-11,858 levels | EC | -0.019(-0.063, 0.025) | 9.3% (30.8%, -12.3%) | 0.400 | -0.186 | -0.205 |
genus.Dorea.id.1997 | Furaneol sulfate levels | EC | 0.026(-0.031, 0.082) | -12.5% (15.0%, -40.0%) | 0.373 | -0.231 | -0.205 |
genus.Turicibacter.id.2162 | Mannose to mannitol to sorbitol ratio | EC | 0.017(-0.005, 0.039) | -14.0% (4.5%, -32.4%) | 0.138 | -0.138 | -0.121 |
family.FamilyXI.id.1936 | X-22,509 levels | EC | -0.016(-0.035, 0.003) | -18.7% (-40.7%, 3.3%) | 0.096 | 0.102 | 0.086 |
family.FamilyXI.id.1936 | Cytosine levels | EC | -0.017(-0.034, -0.000) | -19.7% (-39.1%, -0.4%) | 0.046 | 0.103 | 0.086 |
family.FamilyXI.id.1936 | Glyco-beta-muricholate levels | EC | 0.008(-0.003, 0.020) | 9.8% (-3.5%, 23.1%) | 0.148 | 0.077 | 0.086 |
family.FamilyXI.id.1936 | Androstenediol (3beta,17beta) disulfate (1) levels | EC | 0.013(-0.000, 0.026) | 15.0% (-0.5%, 30.5%) | 0.058 | 0.073 | 0.086 |
family.Erysipelotrichaceae.id.2149 | Glycochenodeoxycholate glucuronide (1) levels | EC | 0.013(-0.023, 0.048) | 6.3% (-11.3%, 23.8%) | 0.484 | 0.190 | 0.202 |
class.Erysipelotrichia.id.2147 | Glycochenodeoxycholate glucuronide (1) levels | EC | 0.013(-0.023, 0.048) | 6.3% (-11.3%, 23.8%) | 0.484 | 0.190 | 0.202 |
genus.Turicibacter.id.2162 | X-21,353 levels | EC | 0.017(-0.005, 0.038) | -13.8% (4.1%, -31.8%) | 0.130 | -0.137 | -0.121 |
genus.Turicibacter.id.2162 | X-18,887 levels | EC | -0.022(-0.049, 0.005) | 18.1% (40.5%, -4.2%) | 0.111 | -0.099 | -0.121 |
genus.Turicibacter.id.2162 | Mannose levels | EC | 0.013(-0.009, 0.034) | -10.4% (7.8%, -28.5%) | 0.262 | -0.133 | -0.121 |
genus.Turicibacter.id.2162 | 3-hydroxydecanoate levels | EC | 0.027(-0.001, 0.054) | -22.3% (0.5%, -45.1%) | 0.055 | -0.148 | -0.121 |
genus.Turicibacter.id.2162 | Quinate levels | EC | -0.015(-0.036, 0.006) | 12.6% (30.1%, -4.9%) | 0.157 | -0.105 | -0.121 |
genus.RuminococcaceaeUCG014.id.11,371 | X-24,243 levels | EC | 0.012(-0.009, 0.033) | -8.5% (6.5%, -23.5%) | 0.267 | -0.153 | -0.141 |
order.Erysipelotrichales.id.2148 | Glycochenodeoxycholate glucuronide (1) levels | EC | 0.013(-0.023, 0.048) | 6.3% (-11.3%, 23.8%) | 0.484 | 0.190 | 0.202 |
genus.RuminococcaceaeUCG014.id.11,371 | X-11,858 levels | EC | 0.016(-0.013, 0.046) | -11.5% (9.4%, -32.5%) | 0.280 | -0.157 | -0.141 |
genus.RuminococcaceaeUCG014.id.11,371 | Cytosine levels | EC | 0.024(-0.007, 0.056) | -17.3% (4.9%, -39.6%) | 0.126 | -0.165 | -0.141 |
genus.RuminococcaceaeUCG014.id.11,371 | Trans 3,4-methyleneheptanoate levels | EC | -0.022(-0.057, 0.012) | 15.8% (40.3%, -8.7%) | 0.207 | -0.119 | -0.141 |
genus.RuminococcaceaeUCG014.id.11,371 | Carboxyethyl-gaba levels | EC | 0.016(-0.008, 0.040) | -11.2% (5.8%, -28.2%) | 0.197 | -0.157 | -0.141 |