Table 2 The role of Nrf2 in oocyte cell
Author et al | Animal type | Model | Component used to target Nrf2 signaling pathway | Outcomes |
|---|---|---|---|---|
Fan et al. [58] | Mouse | In vitro | N-acetyl-cysteine | • Promoted the nuclear translocation of Nrf2 • Activated the expression of superoxide dismutase and glutathione peroxidase, Removed excessive reactive oxygen species • Reduced mitochondria damage |
Huang et al. [59] | Bovine | In vitro | Epigallocatechin-3-gallate (50 μM) | • Improved the oocyte maturation • Increased mRNA abundance of Nrf2, SOD1, CAT, and GPX4 |
Ma et al. [61] | Mouse | In vitro | Brusatol (200 nM) | • Disrupted oocyte maturation through decreasing Nrf2-Cyclin B1 signaling pathway |
Mohammed et al. [60] | Buffalo |  | Myostatin inhibitor | • Downregulated the expression of Nrf2 and reduced the fertilization efficiency and cleavage and blastocyst rates |
Yoon et al. [62] | Porcine |  | Myostatin | • Modulated oocyte maturation by regulating p38 MAPK phosphorylation following by regulating Keap1-Nrf2 mechanism, thus reduces intracellular ROS level during IVM |
Yoon et al. [63] | Porcine | In vitro | Cumulus-derived somatic cells | • Increased expression of Nrf2 in oocyte and granulosa cells • Improved the developmental potential • of IVF- and PA-derived porcine |
Park et al. [67] | Porcine | In vitro | equine amniotic fluid mesenchymal stem cell conditioned medium passages 7 | • Increased Nrf2 in cumulus cell mediated oocyte maturation |
Kim et al. [64] | Porcine | In vitro | Melatonin as Nrf2 activator Brusatol as Nrf2 inhibitor | • Melatonin upregulated Nrf2 signaling, resulting in the upregulation of catalase • Brusatol downregulated Nrf2, resulting in the downregulation of catalase |
Yang et al. [65] | Porcine | In vitro | Heat stress as Nrf2 activator Melatonin as Nrf2 inhibitor | • Heat stress reduced maturation Rate, formation of α-tubulin, and F-actin, and expression of CDK1 and GDF9 and increased the expression of HSP70 and NRF2 • Melatonin increased maturation rate, formation of α-tubulin and F-actin, and expression of HSP70 and reduced the expression Nrf2 |
Yang et al. [66] | Mouse | In vitro | Rapamycin (10 nM) | • Increased the expression of Nrf2 in IVM oocytes |
Xiang et al. [76] | Porcine | In vitro | Astaxanthin (2.5 µM) | • upregulated the SOD1, SOD2 GPX4 expression and alleviated OS • Enhanced maturation quality and subsequent embryo development of both fresh and vitrified porcine oocytes • Decreased cathepsin B activity, rescued lysosomal function, • Increased mitochondrial activity |
Jiang et al. [68] | Mouse | In vivo | Lead | • Increased the transcription levels of Nrf2, CAT, GST, HO-1, GPX, GCLC, GCLM, and SOD • Enhanced ROS and MDA • Decreased antioxidant activity • Suppressed that of Keap1 • decreases the mitochondria |
Qiao et al. [69] | Mouse | In vivo | Oral administration isoniazid (40 mg/kg/day) | • Increased the level of ROS and activated the Keap1-Nrf2 pathway • Caused apoptosis of oocytes and mitochondrial dysfunction |