Fig. 2

Representative number of days in each estrus stage. a The observation of estrus stages in rats began on the 19th day of the experiment and was continually performed once a day for 10 consecutive days and ended on the 28th day. #P < 0.05, ##P < 0.01 and ###P < 0.001, compared with the control group; *P < 0.05, compared with the model group (n = 20). b The observation of estrus stages in mice began on the 22nd day of the experiment and was continually performed once a day for 10 consecutive days and ended on the 28th day. *P < 0.05, compared with the model group (n = 20). Data are presented as mean ± standard deviation of the mean